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. Author manuscript; available in PMC: 2015 Apr 14.
Published in final edited form as: Dev Cell. 2014 Apr 14;29(1):3–4. doi: 10.1016/j.devcel.2014.03.018

Figure 1. The Role of Retromer in Neurons.

Figure 1

Left: Simplified view of endosomal trafficking pathways throughout the cell. The classical retromer pathway can be seen from the endosome to the TGN, as well as the pathway identified by Choy et al. (2014) from the endosome to the plasma membrane. Retromer tubules are shown in green.

Center: Structure and domains of a neuron.

Right: Model of dendritic receptor delivery to plasma membrane by retromer. β2ARs (blue) are delivered and function at the shaft, whereas neurotransmitter receptors such as AMPA- or NMDA-type glutamate receptors (red) function at the spine. Retromer tubules are shown in green.