FIG. 2.

miRNAs are differentially regulated in response to IR. On exposure to IR, miRNA expression is often dysregulated. IR induces some miRNAs, while others are repressed, a decision likely dependent on the target genes involved. A summary of the miRNAs discussed in this review whose expression changes in response to IR can be found in this diagram. On the left and right are lists of miRNAs whose induction or repression, respectively, have been observed. In the center are miRNAs where both induction and repression have been observed in different cell types. Interestingly, the largest group of miRNAs exists in the center, illustrating how different the miRNA profile can be from one cell type to the next. Bold miRNAs function in multiple aspects of the DDR. Additional underlining identifies miRNA families that are involved in almost every stage of the DDR.