Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Mar 24;4(1):202–219. doi: 10.3390/brainsci4010202

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Neuroprotective effects of NTF secreting MSCs. Sparing of NeuN-positive (left) and Darpp-32-positive (right) cells was observed in YAC 128 mice that received striatal transplants of mesenchymal stem cells (MSCs) that were genetically altered to over-express brain derived neurotrophic factor (YAC + BDNF), but not in mice that received transplants of MSCs that were genetically modified to over-express nerve growth factor (YAC + NGF), a combination of MSCs that over-expressed both NGF and BDNF (YAC + BDNF/NGF), or unaltered MSCs (YAC + MSC). Note: * indicates a significant difference from WT + DMEM; ^† indicates a significant difference from YAC + DMEM [40].