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. 2014 Jun 23;4:5403. doi: 10.1038/srep05403

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(A) Random Walk with Restart algorithm was used to score all proteins in the PPI network for their network proximity to the seed node of LCN2. The node size in the PPI sub-network is designed in a gradient according to their scores. (B) The DEGs were extracted from (A) to better show their size. (C) The DEGs were re-arranged according to their closeness to LCN2 protein. The more negative the log10-transformed score, the further the node from LCN2. DEGs were classified into seven layers (from A to G, the Y axis) according to their range of scores as described in the Result section.