Table 1. Topological parameters of three DEG PPI sub-networks.

PPI sub-network	y = βxa	Number of nodes	Number of edges	R2	Correlation	Clustering coefficienta	Network centralizationb	Network densityc	Network diameterd
Downregulated DEGs	y = 226.33x−1.132	834	7005	0.844	0.782	0.365	0.621	0.020	6
Upregulated DEGs	y = 515.01x−1.172	1813	23380	0.814	0.662	0.331	0.803	0.014	6
Total DEGs	y = 849.12x−1.218	2458	33671	0.866	0.696	0.306	0.739	0.011	6

^aClustering coefficient is a measure of the degree to which nodes in a graph tend to cluster together.

^bNetwork centralization measures the degree of the effect when removing some central nodes in the whole network.

^cNetwork density describes the portion of the potential connections in a network that are actual connections.

^dNetwork diameter representative of the linear size of a network.