Figure 5. Longitudinal pattern of PIGF concentrations.

The data presented in Figure 4 were examined as longitudinal values for individual women. In 27 of the women who went on to develop preeclampsia, (A) the concentration of PIGF was similar to that in women with normal pregnancy outcome, prior to and with clinical preeclampsia. Normal pregnancy findings are illustrated in gray as median (solid line) or 95% confidence intervals (dashed line) in both A and B. In A, the results from women with preeclampsia are in blue (median solid. 95% confidence interval, dashed). The other 23 women who developed preeclampsia manifested a very different pattern (B), with no overlap with normal values, being less than the 95% confidence intervals of normal results from 15 weeks’ gestational age. Results from these women with preeclampsia are in red (Median solid 95% confidence intervals, dashed.) Reprinted from Powers et al. 2012, with permission from Wolters Kluwer Health.