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. 2014 Jun 14;63(7):2284–2296. doi: 10.2337/db13-1502

Figure 1.

Figure 1

Mogat1 expression is increased in obese mice in a PPARγ-dependent manner. A: The schematic depicts the two metabolic pathways for triglyceride synthesis. B: Hepatic Mogat1 expression in mice fed chow containing 60% fat or 10% fat for 14 weeks. The scatter plot (right) depicts the relationship between liver TAG content and Mogat expression in individual mice. C: Hepatic Mogat expression in ob/ob and lean ob/+ control mice. D: Hepatic MGAT activity in ob/ob and lean ob/+ control mice. E: Hepatic TAG content in WT or liver-specific PPARγ−/− mice fed a low- or high-fat diet for 14 weeks. F: Hepatic Mogat1 expression in WT or liver-specific PPARγ−/− mice fed a low- or high-fat diet for 14 weeks. *P < 0.05 vs. lean controls; **P < 0.05 vs. lean and DIO WT mice. AU, arbitrary unit; FA, fatty acid; MAG, monoacylglycerol; P, phosphate; PA, phosphatidic acid.