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. 2014 Jun 14;63(7):2464–2473. doi: 10.2337/db13-0835

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© 2014 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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A: Chemical structures of BF175 and BF62. B: Effects of the indicated doses of BF175 or BF62 on the binding of MED15-KIX to purified Flag-tagged SREBP-1a by GST pull-down assays. C: Effects of BF175 (50 µmol/L) on the binding of SREBP1a-TAD to overexpressed Flag-tagged MED15 in HEK293 cell lysates by GST pull-down assays. D: Effects of 50 µmol/L BF175 or BF62 on the activity of SREBP1a-TAD in HepG2 cells by dual-luciferase assays. Data represent the mean ± SD (n = 3). *P < 0.05; #P < 0.01 vs. control (DMSO).