Table 4.
Effect of GA on apoptosis of myeloma cells-binding of annexin V. The increase in annexin V binding cells relative to the control after 24 and 48 hours exposure to a 100 nM dose of GA and its derivatives. Results are from three independent experiments.
| U266 | INA6 | |||
|---|---|---|---|---|
| 24 hours | 48 hours | 24 hours | 48 hours | |
| GA | + | ++ | + | +++ |
| 17AEP-GA | + | ++ | + | +++ |
| 17DMAP-GA | + | + | + | ++ |
| 17AAG | + | + | + | ++ |
| 17DMAG | + | ++ | + | +++ |
The following convention was used for this experiment:
+ Up to 30% apoptotic cells++ Up to 50% apoptotic cells+++Greater than 50% apoptotic cells