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. 2014 Jun 23;5:288. doi: 10.3389/fimmu.2014.00288

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Copyright © 2014 Richardson and Williams.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structures of the C-type lectin domains of (A) human MCL (PDB: 3whd); (B) human Mincle (PDB: 3wh3); (C) bovine Mincle complex with trehalose (PDB: 4kzv); (D) interactions with Ca²⁺ at the primary glucose binding site of bovine Mincle; and (E) putative hydrophobic channel adjacent to the primary glucose binding site of bovine Mincle complex with trehalose (the protein surface is colored according to the underlying atoms: light green, nitrogen/oxygen; dark green, carbon).