Table 4.
Means and standard deviations of biochemical parameters and ERPs values in PKU subjects.
| T1 (n = 17) | T2 (n = 17) | p* | ≤13 years (n = 6) |
>13 years (n = 11) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| T1 | T2 | p* | T1 | T2 | p* | |||||
| Blood Phe (μM) | 571.6 ± 192.9 | 1129.2 ± 177.3 | <0.001 | 457.3 ± 200.5 | 1120.8 ± 253.7 | <0.001 | 634.4 ± 165.3 | 1133.5 ± 134.4 | <0.001 | |
| Blood Tyr (μM) | 58.9 ± 35.2 | 63.6 ± 37.9 | 0.70 | 52.6 ± 16.9 | 62.7 ± 39.4 | 0.58 | 62.3 ± 42.5 | 64.2 ± 39.1 | 0.91 | |
| Blood Phe/Tyr | 12.2 ± 8.2 | 21.9 ± 8.2 | 0.001 | 9.8 ± 5.2 | 21.7 ± 8.7 | 0.02 | 13.4 ± 9.2 | 22.8 ± 8.5 | 0.04 | |
| IDAP | Cz | 0.6 ± 0.9 | 1.2 ± 1.9 | 0.22 | 0.8 ± 1.3 | 2.3 ± 3.1 | 0.17 | 0.5 ± 0.6 | 0.6 ± 0.6 | 0.55 |
| MMN | ||||||||||
| Deviant 1 | ||||||||||
| Lat (ms) | Fz | 261.1 ± 44.8 | 239.8 ± 47.9 | 0.33 | 230.6 ± 28.7 | 247.1 ± 44.5 | 0.41 | 263.3 ± 37.9 | 240.9 ± 51.6 | 0.18 |
| Amp (μV) | Fz | -2.1 ± 1.8 | -2.9 ± 1.5 | 0.23 | -3.6 ± 0.7 | -3.5 ± 1.5 | 0.79 | -1.4 ± 1.7 | -2.5 ± 1.5 | 0.11 |
| Deviant 2 | ||||||||||
| Lat (ms) | Fz | 250.4 ± 37.4 | 273.8 ± 28.6 | 0.18 | 228.9 ± 65.2 | 279.2 ± 30.1 | 0.30 | 250.5 ± 24.3 | 271.6 ± 29.3 | 0.13 |
| Amp (μV) | Fz | -1.2 ± 2.2 | -1.3 ± 1.5 | 0.27 | -1.9 ± 3.2 | -1.2 ± 2.6 | 0.51 | -0.3 ± 1.8 | -1.3 ± 1.1 | 0.13 |
| Deviant 3 | ||||||||||
| Lat (ms) | Fz | 237.2 ± 35.4 | 239.3 ± 27.5 | 0.93 | 246.3 ± 40.7 | 250.5 ± 36.8 | 0.69 | 234.8 ± 33.8 | 232.5 ± 19.3 | 0.80 |
| Amp (μV) | Fz | -3.9 ± 1.9 | -3.1 ± 2.5 | 0.16 | -5.2 ± 1.3 | -3.9 ± 2.5 | 0.31 | -3.3 ± 2.1 | -2.6 ± 2.5 | 0.47 |
| P300 | ||||||||||
| Counting | ||||||||||
| Lat (ms) | ||||||||||
| N1 | Fz | 148.3 ± 24.5 | 128.6 ± 22.8 | 0.07 | 170.7 ± 15.5 | 132.5 ± 29.5 | 0.06 | 136.1 ± 19.4 | 126.4 ± 19.9 | 0.27 |
| Cz | 131.2 ± 17.2 | 127.1 ± 18.8 | 0.46 | 144.1 ± 17.8 | 136.6 ± 25.4 | 0.44 | 124.2 ± 12.7 | 121.9 ± 12.6 | 0.62 | |
| Pz | 126.6 ± 25.4 | 131.1 ± 21.1 | 0.92 | 137.1 ± 32.5 | 135.6 ± 18.9 | 0.91 | 120.8 ± 19.9 | 128.6 ± 22.6 | 0.37 | |
| P3b | Fz | 381.9 ± 33.9 | 395.3 ± 40.8 | 0.13 | 389.5 ± 31.4 | 408.0 ± 53.1 | 0.12 | 378.7 ± 37.8 | 381.7 ± 25.8 | 0.81 |
| Cz | 377.2 ± 28.4 | 402.3 ± 63.1 | 0.11 | 391.8 ± 29.8 | 428.8 ± 87.7 | 0.21 | 368.5 ± 26.7 | 380.4 ± 30.4 | 0.33 | |
| Pz | 398.4 ± 34.1 | 392.5 ± 60.7 | 0.59 | 410.9 ± 38.1 | 425.8 ± 86.1 | 0.42 | 371.9 ± 27.7 | 377.8 ± 27.5 | 0.57 | |
| Amp (μV) | ||||||||||
| N1 | Fz | −11.2 ± 7.2 | −11.6 ± 7.6 | 0.81 | −16.5 ± 9.6 | −17.3 ± 9.8 | 0.75 | −8.3 ± 3.3 | −8.5 ± 3.9 | 0.84 |
| Cz | −8.5 ± 6.5 | −9.3 ± 6.1 | 0.55 | −11.8 ± 9.4 | −13.1 ± 7.6 | 0.69 | −6.6 ± 3.4 | −7.2 ± 3.8 | 0.62 | |
| Pz | −7.1 ± 5.6 | −6.8 ± 6.2 | 0.87 | −10.5 ± 7.7 | −9.3 ± 8.3 | 0.81 | −5.2 ± 3.3 | −5.4 ± 4.5 | 0.90 | |
| P3b | Fz | 2.3 ± 9.4 | 3.4 ± 8.6 | 0.91 | 0.6 ± 10.4 | 3.1 ± 12.1 | 0.54 | 4.4 ± 8.6 | 3.6 ± 6.4 | 0.61 |
| Cz | 9.7 ± 11.5 | 11.6 ± 7.8 | 0.76 | 9.5 ± 14.7 | 12.3 ± 8.6 | 0.65 | 11.4 ± 9.1 | 11.3 ± 7.6 | 0.91 | |
| Pz | 16.6 ± 12.6 | 18.5 ± 8.6 | 0.91 | 13.3 ± 18.2 | 18.4 ± 8.8 | 0.54 | 19.6 ± 8.4 | 18.5 ± 8.9 | 0.63 | |
| Motor response Lat (ms) |
||||||||||
| N1 | Fz | 138.8 ± 21.6 | 149.8 ± 34.1 | 0.30 | 148.6 ± 23.9 | 168.3 ± 30.6 | 0.28 | 134.4 ± 20.2 | 138.7 ± 32.9 | 0.49 |
| Cz | 131.5 ± 19.9 | 144.5 ± 31.1 | 0.39 | 123.6 ± 27.9 | 164.8 ± 29.3 | 0.15 | 135.1 ± 15.5 | 135.9 ± 30.2 | 0.89 | |
| Pz | 125.9 ± 26.1 | 133.4 ± 20.8 | 0.75 | 119.9 ± 30.9 | 149.4 ± 15.7 | 0.14 | 128.6 ± 24.8 | 127.1 ± 20.2 | 0.86 | |
| P3b | Fz | 371.9 ± 37.3 | 387.2 ± 37.1 | 0.18 | 377.1 ± 24.9 | 415.7 ± 60.6 | 0.36 | 363.1 ± 36.3 | 372.8 ± 13.7 | 0.34 |
| Cz | 370.9 ± 45.2 | 377.5 ± 28.6 | 0.37 | 397.6 ± 34.6 | 398.6 ± 23.0 | 0.97 | 350.0 ± 37.1 | 365.2 ± 23.6 | 0.22 | |
| Pz | 373.9 ± 43.5 | 381.1 ± 48.1 | 0.67 | 393.3 ± 37.7 | 414.8 ± 61.7 | 0.59 | 365.1 ± 44.7 | 363.1 ± 34.1 | 0.84 | |
| Amp (μV) | ||||||||||
| N1 | Fz | −8.7 ± 6.3 | −13.5 ± 10.1 | 0.16 | −10.2 ± 8.9 | −19.9 ± 8.6 | 0.09 | −8.1 ± 5.0 | −8.3 ± 5.1 | 0.88 |
| Cz | −7.9 ± 6.1 | −9.8 ± 6.9 | 0.95 | −9.3 ± 9.1 | −16.1 ± 6.7 | 0.19 | −7.2 ± 4.6 | −6.1 ± 3.8 | 0.33 | |
| Pz | −5.7 ± 4.3 | −7.1 ± 7.7 | 0.87 | −7.7 ± 6.4 | −12.7 ± 8.1 | 0.36 | −4.7 ± 2.8 | −3.2 ± 3.9 | 0.28 | |
| P3b | Fz | 3.1 ± 6.9 | 4.6 ± 7.3 | 0.91 | 1.7 ± 6.2 | 1.5 ± 10.4 | 0.96 | 4.8 ± 7.4 | 5.8 ± 6.2 | 0.44 |
| Cz | 10.6 ± 8.8 | 9.6 ± 7.4 | 0.55 | 12.9 ± 9.7 | 6.5 ± 5.2 | 0.12 | 11.0 ± 8.1 | 12.3 ± 6.4 | 0.41 | |
| Pz | 21.4 ± 8.7 | 21.1 ± 8.2 | 0.75 | 25.7 ± 10.2 | 21.2 ± 8.3 | 0.34 | 19.9 ± 7.9 | 22.1 ± 8.2 | 0.14 | |
| RT (ms) | 423.3 ± 116.8 | 443.7 ± 139.6 | 0.17 | 551.3 ± 64.9 | 607.3 ± 82.7 | 0.05 | 553.4 ± 67.4 | 554.5 ± 54.3 | 0.96 | |
| CNV | ||||||||||
| Tot area (μV) | Fz | −8441.2 ± 4370.5 | −6376.5 ± 5976.2 | 0.06 | −8016.7 ± 4675.5 | −3633.4 ± 3245.7 | 0.03 | −8672.7 ± 4411.5 | −7872.7 ± 6700.6 | 0.52 |
| Cz | −8558.2 ± 4488.8 | −5600.0 ± 5041.2 | 0.02 | −9433.9 ± 5795.4 | −2816.6 ± 4159.8 | 0.02 | −8081.8 ± 3838.9 | −7118.2 ± 4982.7 | 0.36 | |
| Pz | −7194.1 ± 5184.7 | −3705.6 ± 4033.8 | 0.02 | −10433.0 ± 7085.5 | −1900.0 ± 2345.2 | 0.03 | −5427.2 ± 2860.4 | −4690.5 ± 4501.4 | 0.43 | |
| W1 | Fz | −960.7 ± 901.7 | −643.3 ± 1290.4 | 0.13 | −704.1 ± 739.4 | −378.2 ± 777.3 | 0.32 | −1100.6 ± 983.4 | −787.9 ± 1515.4 | 0.19 |
| Cz | −429.3 ± 688.5 | −282.9 ± 956.0 | 0.26 | −29.2 ± 390.8 | 78.3 ± 337.6 | 0.67 | −648.1 ± 730.4 | −479.9 ± 1133.2 | 0.37 | |
| Pz | 31.6 ± 869.5 | −132.0 ± 1006.4 | 0.71 | 655.0 ± 684.3 | 324.4 ± 465.6 | 0.42 | −308.7 ± 784.4 | −381.1 ± 1148.4 | 0.84 | |
| W2 | Fz | −1508.7 ± 810.4 | −1263.6 ± 1230.9 | 0.29 | −1358.3 ± 955.4 | −635.1 ± 1124.8 | 0.11 | −1591.1 ± 757.2 | −1606.4 ± 1193.9 | 0.95 |
| Cz | −1786.3 ± 1047.7 | −1390.6 ± 1287.8 | 0.28 | −2068.7 ± 1445.1 | −734.9 ± 1409.4 | 0.05 | −1632.5 ± 798.8 | −1748.3 ± 1123.2 | 0.61 | |
| Pz | −1662.1 ± 1208.2 | −901.8 ± 910.7 | 0.05 | −2498.5 ± 1609.5 | −426.1 ± 848.8 | 0.006 | −1205.9 ± 625.8 | −1161.3 ± 869.9 | 0.79 | |
| RT (ms) | 337.9 ± 88.8 | 363.4 ± 115.3 | 0.14 | 439.2 ± 62.8 | 485.3 ± 90.2 | 0.08 | 282.7 ± 33.9 | 296.9 ± 58.6 | 0.38 | |
* t-test.
Significant data are in the bold font.