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. 2014 Jun 15;28(12):1278–1290. doi: 10.1101/gad.239749.114

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Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — The 4/5 region of LDB1 is required for regulation of FOG1-dependent genes. Depicted are representative LDB1 4/5-independent (left panels) and 4/5-dependent (middle panels) LDB1 complex-occupied genes or regulatory elements and 4/5-dependent genes occupied by LDB1 but not GATA1 (right panels) in induced LDB1 knockdown MEL cells expressing LDB1 FL or LDB1 Δ4/5 or with an empty vector. (A) qRT–PCR validation of gene expression. FOG1 (B) and GATA1 (C) occupancy determined by ChIP. X-axis designations for B and C are the same. For representative genome browser screen shots, see Supplemental Figure S9. Error bars indicate SEM; n = 3 biological replicates. Values are compared with the value for LDB1 FL. (*) P < 0.05 by Student’s t-test.