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A model for the regulation of PKR in the cell cycle. (A) In interphase, cytosolic PKR remains inactive, as PKR-activating dsRNAs are sequestered in the nucleus. (B) However, during mitosis, disintegration of the nuclear envelope allows interaction between PKR and dsRNAs. Activated PKR then catalyzes phosphorylation of eIF2α and JNK to regulate mitotic translation and coordinate mitotic processes.
