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. 2014 Jun 15;28(12):1337–1350. doi: 10.1101/gad.240416.114

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© 2014 Liu et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Pax5 restoration disables the leukemia-initiating capacity of B-ALL cells. (A) Strategy for testing leukemia initiation properties of B-ALL cells following Pax5 restoration. (B) Peripheral WBC counts from secondary recipient mice 14 d following transplant with 2 million leukemia cells isolated from primary recipient mice that were treated as indicated. n = 2 mice for each time point. Horizontal lines indicate average counts. (C) Flow cytometric analysis of leukemia burden (GFP⁺CD19⁺ cells) in the blood of secondary recipient mice 14 d following transplant as described in B.