. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: J Endocrinol. 2014 Jul;222(1):27–41. doi: 10.1530/JOE-13-0455

Table 1.

Adiposity, serum leptin and BAT UPC1 levels following leptin antagonist overexpression in Exp. 1.

	rAAV-Control	rAAV-Antagonist into MBH	rAAV-Antagonist into VTA
Adiposity, g	7.31± 0.43^a	12.23± 0.81^b	10.19± 0.89^c
Serum Leptin (ng/ml)	5.8 ± 0.3^a	10.6 ± 0.9^b	8.9 ± 1.0^c
UCP1/ μg Arbitrary units	100 ± 10.8^a	46.8 ± 12.8^c	87.4 ± 17.6

Data represent the mean ± SE of 13 (control) or 7-8 (experimental groups) rats.

Adiposity represents the sum of perirenal, retroperitoneal and epididymal white adipose tissues at death.

The value of UCP1, expressed as UCP1/ μg BAT protein, in rAAV-Control for is arbitrarily set to 100 with SE adjusted proportionally with remaining groups normalized to the level in rAAV-Control.

P<0.0002 (Adiposity and Serum leptin) or P<0.05 (UCP1) for difference among groups at day 14 by one-way ANOVA.

P<0.001 for difference from control group by Newman-Keuls post-hoc analysis.

P<0.05 for difference from control group by Newman-Keuls post-hoc analysis.