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. 2014 Jun 23;5:231. doi: 10.3389/fphys.2014.00231

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Copyright © 2014 Wang, Ross, Cai, Cong, Daimon, Carlson, Egan, Siddiqui, Maudsley and Martin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Growth hormone changes in HD subjects. Plasma BDNF, growth hormone (GH), Agouti-related protein (AgRP), and prolactin (PRL) were measured using the Millipore brain-derived protein panel. Data are mean ± s.e.m., n = 8–16. Statistical analysis was performed using One-Way ANOVA followed by Bonferroni's multiple-comparison test, p ≤ 0.05 (^*, †, ‡, §) and p ≤ 0.01 (^**, ††, ‡‡, §§) were considered statistically significant. ^* Represents significant difference against familial control; ^† represents significant difference against BLSA pre-manifest control; ^‡ represents significant difference against BLSA manifest control and ^§ represent significant difference against pre-manifest HD subjects. No change was found in BDNF levels (A). Reduction in GH was observed in manifest HD subjects (B). Elevation of AgRP was found in pre-manifest group (C). Reduction of PRL was observed in both pre- and manifest subjects (D).