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. Author manuscript; available in PMC: 2014 Jun 23.
Published in final edited form as: Respir Physiol Neurobiol. 2012 Feb 2;181(1):99–108. doi: 10.1016/j.resp.2012.01.011

Figure 10. Effect of cyclooxygenase, leukotrienes, and histamine on IF and ACh-elicted force generation of epithelial-intact human bronchi.

Figure 10

IF in human bronchi determined following and during the continued presence of indomethacin, AA-861, pyrilamine, and the combination of indomethacin and AA-861 did not affect IF. However, indomethacin, AA-861 and the combination of indomethacin and AA-861 significantly decreased ACh-elicited force generation, *P < 0.01; # P < 0.05; $ P < 0.05, respectively compared with control. There is no significant difference in total force between the different groups. Data are the mean ± SE. Mean of 17 experiments, with tissue from 17 individuals. PSS containing 1 μM AA-861 or 10 μM pyrilamine resulted in a significant decrease in PSS buffer basal tone in ASM (P < 0.01, Data not shown). However, PSS buffer with 10 μM indomethacin had no significant effect on PSS buffer basal tone in ASM (Data not shown).