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. Author manuscript; available in PMC: 2014 Jun 23.
Published in final edited form as: Respir Physiol Neurobiol. 2012 Feb 2;181(1):99–108. doi: 10.1016/j.resp.2012.01.011

Figure 8. Influence of muscarinic antagonist on IF of epithelial-intact human bronchi and basal [Ca2+]i in human airway smooth muscle cells.

Figure 8

Atropine showed no effect on IF at concentration of 10-9 M to 10-3 M, * P < 0.01 compared with control (Fig. 8A). Data were the mean ± SE. Mean of 4 experiments, with tissue from 4 individuals. PSS containing 10-4 or 10-3 M atropine resulted in a significant decrease in PSS buffer basal tone in ASM (P < 0.01 and P < 0.001, respectively, data not shown). However, PSS buffer with 10-9 to10-5 M atropine had no significant effect on PSS buffer basal tone in ASM (Data not shown). However, the acute addition of atropine (10-9 to 10-4 M) to HBSMCs resulted in no significant changes in basal [Ca2+]i (results are mean ± SE, n = 3 experiments, at least 50 individual cells analyzed per experiment) (Fig. 8B).