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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Int Urol Nephrol. 2013 Aug 25;46(2):379–388. doi: 10.1007/s11255-013-0522-z

Figure 3.

Figure 3

KIM-1 Domains (panel A). KIM-1 is a type one transmembrane protein. The larger extracellular portion is made up of an immunoglobulin-like (Ig) domain and a mucin-like (Mucin) domain, where Exon 4 is located. The transmembrane domain (TR) and the short, intracellular segment (IC) are also indicated (based on reference 2). KIM-1 Exons and Mutations (panel B). The nine exons are represented together with the positions of the nested primers (horizontal sets of arrows, → ←) that were used to amplify the genomic DNA sequence. An expanded view of exon 4 is shown to indicate the three mutations we detected: class 1, class 2, and class 3 (see deduced amino acid alterations from RCC in Table 4).