Table 5.

Summary of 3 Studies Using Urine KIM-1 (uKIM-1) to Detect Renal Cell Carcinoma (RCC)

	KIM-1 Antibodies used for ELISA	Retrospective Data	Prospective Data	Follow-up period	Major Findings
Han et al, 2005 (reference 12)	Monoclonal KIM-1 antibody from Bonventre's lab	Yes Con n = 30 RCC n = 42	Yes Con n = NA RCC n = 5	4 –6 weeks	RCC cases had higher levels of uKIM-1 and 5 RCC cases had reduced uKIM-1 after nephrectomy
Morrissey et al 2011 (reference 14)	Polyclonal KIM-1 antibody, commercially available with R & D system	No	Yes Con n = 41 RCC n = 51	1 – 3 months	Higher levels of uKIM-1 in RCC cases were significantly reduced following nephrectomy
Zhang et al, current study	Monoclonal KIM-1 antibody from Bonventre's lab and commercially available with Bioassayworks LCC	No	Yes KIM-1 − n = 7 KIM-1 + n = 12	1 month	High levels of uKIM-1 in KIM-1 positive group were significantly reduced after nephrectomy