Model of LV myofiber structure and twist mechanics. The contractile motion of the LV is dictated by the spiral structure of the myocardial fibers. Subendocardial myofibers are wrapped in a right-handed helix, sub-epicardial fibers are wrapped in a left-handed helix, and mid-myocardial fibers are oriented parallel to the circumferential direction. Following a brief clockwise rotation of the apex and opposite (counterclockwise) rotation of the base during isovolumic contraction, the subendocardial and subepicardial fibers shorten concurrently during ejection, causing a “wringing” motion of the apex and base in counterclockwise and clockwise directions, respectively, when viewed from the apex. “Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2013. All Rights Reserved.”