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. 2014 May 29;111(24):8850–8855. doi: 10.1073/pnas.1408233111

Fig. 2.

Fig. 2.

Postnatal generation of cardiomyocytes in the actinCreER;MADM model. (A) MADM labeling can occur in any cell type to lead to labeled cardiomyocytes. (B and C) Single-labeled sibling cardiomyocytes exhibit intimate end-on contact. (Scale bars, 10 µm.) (D) Single-labeled RFP cells in a large vessel. [Scale bars, 70 µm (Insets, 5 µm)]. (E and F) Cardiomyocytes and smooth muscle cells do not share MADM labeling. (Scale bars, 20 µm.) (G) Sparse c-kit+ cells (white cells within inset box) did not demonstrate MADM labeling. [Scale bar, 30 µm (Inset, 7.5 µm)]. (H and I) Sections of 10-d-old (H) and 4.5-wk-old mice (I) analyzed after TM pulse reveal a temporal decrease in single-labeling frequency. [Scale bars, 100 µm (H) and 1 mm (I).] (n = 3,3 mice). (J) TM administration timeline for I–H.