Table 1.
Baseline Differences in Demographic and Clinical Factors, and Cognitive Test Results by Treatment Group
| DOMAIN | TEST | S (N=14) | LE (N=25) | HE (N=30) | P-Value |
|---|---|---|---|---|---|
|
Mean (SD)
| |||||
| Attention | DSpan1 | −0.2 (0.6) | −0.1 (0.8) | 0.03 (1.0) | .672 |
| Psychomotor Speed | DSymbol1 | 0.4 (0.6) | 0.3 (1.0) | 0.3 (1.0) | .944 |
| TMTA1 | 0.7 (0.6) | 0.3 (0.7) | 0.1 (1.3) | .787 | |
| Learning and Memory | HVLT1 | −0.4 (0.9) | −1.2 (1.5) | −1.1 (1.2) | .561 |
| Executive | TMTB1 | −0.2 (2.5) | −0.4 (1.8) | −0.8 (2.1) | .427 |
| Language | COWA1 | 0.5 (0.9) | 0.2 (0.9) | 0.2 (1.0) | .684 |
| Motor | GPD1 | −0.2 (0.8) | −0 .9 (1.0) | −1.1 (1.7) | .135 |
| GPND1 | −0.5 (0.9) | −0.6 (0.9) | −0.7 (1.1) | .429 | |
| Age (years) | 34.4 (5.7) | 32.4 (7.4) | 28.4 (7.5) | .065 | |
| Education (years) | 15.4 (1.9) | 14.5 (3.1) | 14.3 (2.6) | .385 | |
| Depression | CESD2 | 10.2 (9.7) | 15.6 (11.5) | 12.1 (10.3) | .470 |
| Anxiety | STAIS1 | 0.6 (1.0) | −0.3 (1.2) | 0.1 (1.2) | .103 |
|
% (N) | |||||
| Stage of Disease | |||||
| Stage 1 | 92.9 (13) | 76.0(19) | 60.0 (18) | ||
| Stage 2 | 7.1 (1) | 16.0(4) | 16.7 (5) | .174 | |
| Stage 3 | 0 (0) | 8.0(2) | 23.3 (7) | ||
Note: S=Surveillance; LE=Low Exposure Chemotherapy; HE=High Exposure Chemotherapy
1
Z-score
2
Raw score
DSpan: WAIS-R Digit Span30, DSymbol: WAIS-R Digit Symbol30, TMTA: Trail Making Test A31, HVLT: Hopkins Verbal Learning Test32, TMTB: Trail Making Test B31, COWA: Controlled Oral Word Association33, GPD/ND: Lafayette Grooved Pegboard Dominant/Non-Dominant Hand34, CESD: Center for Epidemiological Studies – Depression18, STAIS: State-Trait Anxiety Inventory – State19