Table 2.
Cognitive Decline From Baseline to Post-treatment by Treatment Group
| DOMAIN | TEST | S (N=11) | LE (N=23) | HE (N=28) | FISHER'S EXACT P (LE vs S) | FISHER'S EXACT P (HE vs S) |
|---|---|---|---|---|---|---|
|
PERCENT DECLINED
| ||||||
| Attention | DSpan | 0 | 0 | 0 | * | * |
| Psychomotor Speed | DSymbol | 0 | 9 | 39 | 1.0 | 0.017 |
| TMTA | 0 | 4 | 14 | 1.0 | 0.309 | |
| Learning and Memory | HVLT | 0 | 4 | 0 | 1.0 | * |
| Executive | TMTB | 9 | 4 | 7 | 1.0 | 1.0 |
| Language | COWA | 0 | 0 | 0 | * | * |
| Motor | GPD | 0 | 35 | 39 | 0.034 | 0.017 |
| GPND | 0 | 22 | 14 | 0.150 | 0.309 | |
| Overall Decline# | 0 | 17 | 29 | 0.280 | 0.08 | |
|
MEAN (SD) | ||||||
| Number Tests Declined (ANOVA) | 0.1 (0.3) | 0.8 (0.9) | 1.1 (1.0) | 0.05 | 0.005 | |
Note: S=Surveillance; LE=Low Exposure Chemotherapy; HE=High Exposure Chemotherapy; DSpan: WAIS-R Digit Span, DSymbol: WAIS-R Digit Symbol, TMTA: Trail Making Test A, HVLT: Hopkins Verbal Learning Test, TMTB: Trail Making Test B, COWA: Controlled Oral Word Association, GPD/ND: Lafayette Grooved Pegboard Dominant/Non-Dominant Hand
#
Decline on ≥ 2 tests
*
No statistics computed due to zero declines in both groups