Figure 4.

(A) Representative CB-immunostained hippocampi from the normal group (a, e, i), pilocarpine-only group (b, f, j), pilocarpine plus androsterone 200 mg group (c, g, k), and androsterone-only group (d, h, l). In the pilocarpine plus androsterone group, CB-positive neurons increased in the stratum radiatum of the CA1 and CA3 regions, the stratum lucidum of the CA3 region, and the stratum molecular of the DG compared to the other groups. Insets show the high-magnified images c, e, g and k. (B) Quantitation of CB-positive cells in the stratum radiatum of hippocampus. In the pilocarpine plus androsterone groups, CB-positive interneuron cells increased dose dependently. ^*p<0.001