Table 1.
Characteristics of studies included in the present meta-analysis.
| Studies | Year | Country | Ethnicity | Type | Source of controls | Sample size | SNP studied | Genotyping method | HWE |
|---|---|---|---|---|---|---|---|---|---|
| Harada et al. [31] | 2009 | Japan | Asian | AA | PB | 453/719 | −607C/A; −137G/C |
Taqman | 0.29; 0.48 |
| Heinzmann et al. [32] | 2004 | German | Caucasian | AA | PB | 230/269 | −607C/A; −137G/C |
Taqman | 0.68; 0.17 |
| Birbian et al. [33] | 2013 | Indian | Asian | AA | PB | 410/414 | −137G/C | ARMS-PCR | <0.001 |
| Yang et al. [40] | 2009 | China | Asian | AA | PB | 102/100 | −607C/A −137G/C |
PCR-SSP | 0.08; 0.74 |
| Imboden et al. [34] | 2006 | Swiss | Caucasian | AA | HB | 530/5204 | −137G/C | Taqman | 0.37 |
| Lachheb et al. [38] | 2008 | Tunisia | Caucasian | AA | HB | 105/112 | −607C/A | PCR-RFLP | 0.002 |
| Pawlik et al. [35] | 2007 | Poland | Caucasian | AA | PB | 231/305 | −607C/A; −137G/C |
Allele-specific PCR | 0.75; 0.08 |
| Sebelova et al. [10] | 2007 | Czech | Caucasian | AR | HB | 539/312 | −607C/A; −137G/C |
PCR-RFLP | 0.06; 0.80 |
| Shin et al. [37] | 2005 | Korea | Asian | AA | PB | 438/149 | −607C/A; −137G/C |
PCR-sequencing | 0.14; 0.36 |
| Wu et al. [36] | 2012 | China | Asian | AA | PB | 120/120 | −607C/A; −137G/C |
PCR-SSP | 0.05; 0.40 |
| Chen [39] | 2008 | China | Asian | AA | HB | 82/78 | −607C/A; −137G/C |
PCR-SSP | 0.66; 0.89 |
| Ibrahim et al. [41] | 2012 | Egypt | Caucasian | AD | HB | 25/25 | −137G/C | PCR-RFLP | 0.10 |
| Trzeciak et al. [42] | 2010 | Poland | Caucasian | AD | PB | 67/46 | −137G/C | ARMS-PCR | 0.07 |
| Luo et al. [45] | 2008 | China | Asian | AD | PB | 82/100 | −607C/A; −137G/C |
PCR-SSP | 0.62; 0.76 |
| Izakovicova et al. [49] | 2010 | Czech | Caucasian | Allergic disorder | PB | 633/325 | −607C/A; −137G/C |
Taqman | 0.09; 0.71 |
| Lee et al. [46] | 2006 | China | Asian | AR | HB | 160/166 | −607C/A | PCR-RFLP | <0.001 |
| Ming et al. [47] | 2011 | China | Asian | Drug allergy | HB | 606/614 | −607C/A; −137G/C |
PCR-sequencing | 0.07; 0.09 |
| Osawa et al. [44] | 2007 | Japan | Asian | AD | PB | 21/100 | −607C/A; −137G/C |
PCR-sequencing | 0.88; 0.48 |
| Kim et al. [48] | 2011 | Korea | Asian | Drug allergy | PB | 275/196 | −607C/A; −137G/C |
SNaPshot | 0.84; 0.17 |
| Kato et al. [43] | 2009 | Japan | Asian | AD | HB | 160/104 | −137G/C | PCR-RFLP | 0.11 |
| Torres et al. [50] | 2010 | Spain | Caucasian | Henoch-Schönlein purpura | PB | 62/200 | −607C/A; −137G/C |
Taqman | 0.05; 0.10 |
AA, allergic asthma; AD, allergic dermatitis; AR, allergic rhinitis; PB, population-based controls; HB, hospital-based controls; HWE, Hardy-Weinberg equilibrium; PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism; SSP, sequence-specific primers.