Table 2.
Meta-analysis of IL-18 −607C/A and −137G/C polymorphisms with risk of allergic disease.
| Allele model | Dominant model | Recessive model | Homozygous comparison | Heterozygous comparison | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR [95% CI] | P | OR [95% CI] | P | OR [95% CI] | P | OR [95% CI] | P | OR [95% CI] | P | |
| IL-18 −607C/A | A allele versus C allele | AA + AC versus CC | AA versus CC + AC | AA versus CC | AC versus CC | |||||
| Overall | 1.03 [0.91–1.15] | 0.67 | 1.02 [0.85–1.22] | 0.86 | 1.07 [0.88–1.28] | 0.51 | 1.01 [0.77–1.33] | 0.94 | 1.00 [0.83–1.21] | 0.98 |
| Type of disease | ||||||||||
| AA | 0.98 [0.89–1.08] | 0.72 | 0.87 [0.74–1.03] | 0.10 | 1.08 [0.82–1.43] | 0.58 | 0.88 [0.61–1.27] | 0.48 | 0.82 [0.69–0.98] | 0.03 |
| AD | 1.15 [0.81–1.64] | 0.44 | 1.39 [0.80–2.41] | 0.24 | 1.01 [0.55–1.87] | 0.98 | 1.27 [0.61–2.65] | 0.53 | 1.42 [0.79–2.56] | 0.24 |
| AR | 1.05 [0.88–1.24] | 0.60 | 1.36 [0.55–3.34] | 0.51 | 1.00 [0.73–1.36] | 0.98 | 1.21 [0.84–1.75] | 0.30 | 1.49 [0.47–4.78] | 0.50 |
| Other types | 1.02 [0.74–1.43] | 0.89 | 1.02 [0.66–1.60] | 0.92 | 1.09 [0.67–1.78] | 0.72 | 1.09 [0.55–2.18] | 0.80 | 1.03 [0.70–1.51] | 0.88 |
| Ethnicity | ||||||||||
| Asian | 1.04 [0.88–1.24] | 0.61 | 1.10 [0.82–1.46] | 0.53 | 1.02 [0.80–1.31] | 0.85 | 0.96 [0.64–1.45] | 0.86 | 1.12 [0.82–1.52] | 0.47 |
| Caucasian | 0.97 [0.88–1.08] | 0.57 | 0.90 [0.77–1.04] | 0.15 | 1.14 [0.83–1.56] | 0.42 | 1.02 [0.82–1.27] | 0.86 | 0.86 [0.73–1.01] | 0.06 |
| Source of control | ||||||||||
| PB | 0.93 [0.86–1.01] | 0.11 | 0.86 [0.76–0.98] | 0.03 | 0.97 [0.85–1.11] | 0.69 | 0.80 [0.68–0.95] | 0.009 | 0.85 [0.74–0.98] | 0.03 |
| HB | 1.27 [1.03–1.57] | 0.03 | 1.36 [0.94–1.96] | 0.10 | 1.46 [0.97–2.21] | 0.07 | 1.75 [1.14–2.68] | 0.01 | 1.27 [0.84–1.94] | 0.26 |
|
| ||||||||||
| IL-18 −137G/C | C allele versus G allele | CC + CG versus GG | CC versus CG + GG | CC versus GG | CG versus GG | |||||
| Overall | 0.93 [0.80–1.07] | 0.31 | 0.97 [0.82–1.14] | 0.70 | 0.77 [0.58–1.02] | 0.07 | 0.76 [0.55–1.04] | 0.08 | 1.02 [0.88–1.18] | 0.78 |
| Type of disease | ||||||||||
| AA | 0.94 [0.86–1.03] | 0.21 | 0.97 [0.87–1.08] | 0.63 | 0.80 [0.63–1.02] | 0.07 | 0.80 [0.63–1.02] | 0.07 | 1.00 [0.90–1.12] | 0.95 |
| AD | 0.66 [0.30–1.46] | 0.30 | 0.70 [0.29–1.71] | 0.44 | 0.30 [0.15–0.60] | <0.001 | 0.26 [0.12–0.53] | <0.001 | 0.84 [0.38–1.82] | 0.65 |
| AR | 0.93 [0.75–1.16] | 0.51 | 0.94 [0.71–1.25] | 0.68 | 0.81 [0.48–1.37] | 0.43 | 0.80 [0.47–1.37] | 0.42 | 0.97 [0.73–1.30] | 0.85 |
| Other types | 0.96 [0.61–1.53] | 0.87 | 1.00 [0.60–1.66] | 0.99 | 0.71 [0.47–1.09] | 0.12 | 0.70 [0.46–1.08] | 0.11 | 1.05 [0.66–1.68] | 0.84 |
| Ethnicity | ||||||||||
| Asian | 1.05 [0.85–1.30] | 0.64 | 1.12 [0.89–1.39] | 0.34 | 0.78 [0.54–1.12] | 0.18 | 0.81 [0.56–1.16] | 0.25 | 1.15 [0.93–1.43] | 0.20 |
| Caucasian | 0.80 [0.66–0.98] | 0.03 | 0.83 [0.68–1.02] | 0.08 | 0.71 [0.49–1.02] | 0.06 | 0.66 [0.43–1.00] | 0.05 | 0.93 [0.83–1.05] | 0.24 |
| Source of control | ||||||||||
| PB | 0.87 [0.73–1.05] | 0.14 | 0.91 [0.76–1.10] | 0.35 | 0.76 [0.51–1.11] | 0.15 | 0.73 [0.48–1.12] | 0.15 | 0.98 [0.87–1.10] | 0.72 |
| HB | 1.04 [0.77–1.39] | 0.81 | 1.09 [0.79–1.51] | 0.60 | 0.72 [0.54–0.96] | 0.03 | 0.72 [0.53–0.97] | 0.03 | 1.14 [0.85–1.54] | 0.38 |
AA, allergic asthma; AD, allergic dermatitis; AR, allergic rhinitis; PB, population-based control; HB, hospital-based control.