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Correlation of alterations in the surface electrostatic potential in different Cx50 mutants with their intracellular trafficking fates. Four out of 6 mutations showing impaired trafficking (R23T, D47N, E201K, and R205G[Gja8]) involve S.E.P. change, while the other 2 mutations (P88S and P88Q) involve gross structural alteration. On the contrary, only 1 out of 4 mutations showing proper trafficking (V44E) involves S.E.P. change.
