Table 2.
Adjusted mean differences in lung function responses between tiotropium Respimat® doses
|
Response parameter |
Adjusted mean differences between treatments (95% CI), mL |
||
|---|---|---|---|
| Tiotropium Respimat® 5 μg versus tiotropium Respimat® 1.25 μg | Tiotropium Respimat® 5 μg versus tiotropium Respimat® 2.5 μg | Tiotropium Respimat® 2.5 μg versus tiotropium Respimat® 1.25 μg | |
| FEV1 | |||
| Peak FEV1(0-3h) |
50 (2, 98) |
60 (12, 108) |
-10 (-58, 38) |
| Trough FEV1 |
18 (-30, 66) |
11 (-36, 59) |
7 (-41, 54) |
| FEV1 AUC(0-3h) |
49 (3, 95) |
51 (5, 97) |
-2 (-48, 44) |
| FVC | |||
| Peak FVC(0-3h) |
58 (5, 111) |
67 (14, 120) |
-9 (-61, 44) |
| Trough FVC |
44 (-15, 103) |
27 (-33, 86) |
17 (-42, 77) |
| FVC AUC(0-3h) | 74 (22, 0.125) | 63 (11, 114) | 11 (-40, 62) |
AUC, area under the curve; CI, confidence interval; FEV1, forced expiratory volume in 1 second; FEV1 AUC(0-3h), forced expiratory volume in 1 second area under the curve measured within the first 3 hours after dosing; FVC, forced vital capacity; FVC AUC(0-3h), forced vital capacity area under the curve measured within the first 3 hours after dosing; peak FEV1(0-3h), peak forced expiratory volume in 1 second measured within the first 3 hours after dosing; peak FVC(0-3h), peak forced vital capacity measured within the first 3 hours after dosing.