Table 1.
Effects of topoisomerase I and dual inhibitors on Trypanosoma cruzi after 72 h of treatment
| Drugs | Target | IC 50 (μM) | Ultrastructural effects |
|---|---|---|---|
|
Topotecan |
Eukaryotic Topo I Inhibitor |
110 |
Unpacking of nuclear heterochromatin and mitochondrial swelling |
|
Irinotecan |
Eukaryotic Topo I Inhibitor |
> 300 |
No modifications |
|
Baicalein |
Eukaryotic Dual Inhibitor |
62,83 |
No modifications |
|
Luteolin |
Eukaryotic Dual Inhibitor |
> 300 |
No modifications |
| Evodiamine | Eukaryotic Dual Inhibitor | 90,73 | No modifications |