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Mutants obtained in a screen for dsRNA-induced RNAi deficiency
| mutants | alleles | function | homologs | |
|---|---|---|---|---|
| RDR1 | 41 | 26 | RdRP | Tt, At, Ce, Sp |
| RDR2 | 2 | 2 | RdRP | Tt, At, Ce, Sp |
| DCR1 | 2 | 2 | RNase III Dicer | Tt, At, Ce, Sp, Dm, Mm, Hs |
| CID1* | 16 | 7 | nucleotidyl transferase | Tt, At, Ce, Sp, Dm, Mm, Hs |
| PDS1* | 10 | 10 | unknown | Paramecium |
The first alleles to be discovered for the two new genes (*) CID1 and PDS1 were identified by whole-genome sequencing of pooled F2 clones (see Figure 1).
