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. 2014 May 22;42(11):7450–7460. doi: 10.1093/nar/gku334

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Rate of formation of oxidation products from cellular DNA. F98 cells were exposed to ionizing radiation (0–4 kGy), DNA was extracted and digested, and the modified 2′-deoxyribonucleosides were quantified by LC-MS/MS analyses. The formation of 5,6-unsaturated products is shown in the upper panel and that of saturated products in the lower panel. Results obtained from five independent experiments (n = 5). The values for the rate of formation of each product in cellular DNA are given in Table 2.