. 2014 May 3;42(11):7132–7144. doi: 10.1093/nar/gku342

Table 2. Rates of synonymous (K_s) and non-synonymous (K_n) nucleotide substitutions in human-macaque orthologous alternative (alt) and constitutive (con) protein coding sequences. (A) Unfiltered dataset. (B) Highly conserved sequences (K_s ≈ 0) excluded.


Region	K_n/K_s	K_n	K_s	Length	% regions with Ks∼0	% regions with overlapping frames
A.
5′ grey alt	0.427	0.0252 ± 0.0010	0.0827 ± 0.0014	353 ± 16	26	4.3
cCDS alt	0.495	0.0279 ± 0.0005	0.0733 ± 0.0011	257 ± 11	34	6.2
3′ grey alt	0.422	0.0255 ± 0.0005	0.0780 ± 0.0010	570 ± 18	27	13.6

CDS con	0.228	0.0207 ± 0.0004	0.0910 ± 0.0005	905 ± 21	12	18.8
B.


5′ grey alt	0.255	0.0261 ± 0.0012	0.1076 ± 0.0016	441 ± 16
cCDS alt	0.291	0.0292 ± 0.0006	0.1029 ± 0.0014	309 ± 11
3′ grey alt	0.250	0.0257 ± 0.0006	0.1014 ± 0.0012	659 ± 18

CDS con	0.229	0.0225 ± 0.0004	0.0976 ± 0.0008	1002 ± 21

Table 2. Rates of synonymous (Ks) and non-synonymous (Kn) nucleotide substitutions in human-macaque orthologous alternative (alt) and constitutive (con) protein coding sequences. (A) Unfiltered dataset. (B) Highly conserved sequences (Ks ≈ 0) excluded.