Table 2.
Progressive supranuclear palsy features in each incidental PSP and PSP case. Case # corresponds to those in Supplementary Table 1. NFT= neurofibrillary tangles, Tft= tufted astrocytes, Thrn = thorned astrocytes, CB= Coiled bodies.
| incidental PSP | PSP | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Case # | 9 | 30 | 55 | 71 | 97 | 109 | 110 | 111 |
|
| ||||||||
| Clinical Features | n/a | n/a | n/a | Parkinsonism NOS | Dementia | Early Falls, Parkinsonism NOS | Typical PSP | Abnormal Gait and Posture |
| Pathologic Features | ||||||||
| Frontal Cortex | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | Tft | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT | NFT, Tft, Thrn, CB |
| Temporal Cortex | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT | - | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | - | NFT, Tft, Thrn, CB |
| Parietal Cortex | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | - | Tft | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | Tft, Thrn, CB |
| Putamen | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | - | - | NFT, Tft, CB | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT, Thrn |
| Subthalamic Nucleus | NFT | NFT, Tft, Thrn, CB | - | - | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT, Thrn, CB | NFT, Tft, Thrn, CB |
| Globus Palllidus | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | - | - | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT | NFT, Thrn, CB |
| Thalamus | - | NFT, Tft, Thrn, CB | - | - | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT, Thrn, CB | NFT, Tft, CB |
| Substantia Nigra | NFT | NFT, Tft, Thrn, CB | NFT | - | NFT, Tft, Thrn, CB | NFT, Tft, Thrn, CB | NFT, Thrn, CB | NFT |
| Substantia Nigra Pigment Loss | Moderate | Mild | Mild | Mild | Mild | Severe | Mild | Severe |
| Pons | NFT | NFT, Tft, Thrn, CB | NFT | - | NFT, Tft, Thrn, CB | NFT, Thrn, CB | - | |
| Dentate Nucleus | NFT, Tft | NFT, Tft, Thrn, CB | NFT | - | NFT, Thrn | NFT, Tft, CB | - | NFT, Tft, CB |