Table 1.
Whole brain volumes (Vol) estimated based on tissue segmentations derived from SPM, DARTEL, FSL, or ISBNRR.
| SPM | DARTEL | FSL | IBSNRR | ANOVA | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Vol (ml) | Vol (ml) | Vol (ml) | Vol (ml) | Group × Meth | ||||||
| Young | Elderly | Young | Elderly | Young | Elderly | Young | Elderly | F(3, 108) | p | |
| GM | 741 ± 78.1 | 625 ± 53.4 | 688 ± 57.0 | 653 ± 59.9 | 627 ± 58.7 | 563 ± 41.3 | 758 ± 78.3 | 682 ± 61.8 | 31.75 | <0.0001 |
| WM | 450 ± 39.5 | 462 ± 65.3 | 489 ± 42.8 | 489 ± 57.7 | 522 ± 47.6 | 518 ± 63.0 | 415 ± 38.3 | 410 ± 85.6 | 3.69 | <0.05 |
| CSF | 372 ± 77.0 | 479 ± 78.0 | 255 ± 18.1 | 253 ± 24.2 | 281 ± 30.5 | 315 ± 33.3 | 181 ± 17.5 | 215 ± 27.2 | 10.92 | <0.001 |
| %ICV | %ICV | %ICV | %ICV | Group × Meth | ||||||
| Young | Elderly | Young | Elderly | Young | Elderly | Young | Elderly | F(3, 111) | p | |
| GM | 43 ± 2.4 | 36 ± 1.7 | 40 ± 0.9 | 38 ± 1.0 | 36 ± 1.4 | 33 ± 1.4 | 44 ± 1.4 | 40 ± 1.0 | 32.21 | <0.0001 |
| WM | 26 ± 0.7 | 27 ± 1.8 | 28 ± 0.7 | 29 ± 1.1 | 31 ± 1.1 | 30 ± 1.4 | 24 ± 0.9 | 25 ± 1.9 | 3.6 | <0.05 |
| CSF | 22 ± 4.6 | 28 ± 3.6 | 13 ± 0.7 | 14 ± 0.6 | 16 ± 1.2 | 18 ± 1.2 | 10 ± 0.7 | 13 ± 1.1 | 10.6 | <0.001 |
Volumes are expressed in ml (upper part) or as a percentage of the ICV (lower part). Statistical results are reported in the rightmost columns. Post-hoc analyses comparing the Group × Method interaction pairwise between methods are reported in the text.