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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2013 Dec 5;5(2):141–181. doi: 10.1002/wrna.1210

Figure 2.

Figure 2

General overview of the biogenesis of various classes of small RNA. Extremely generalized biogenesis pathways for the classes of small RNA listed in Table 2 are provided for reference. Classes of small RNA cargo are depicted and labelled numerically on the far left. Domains catalyzing or providing assistance in various lineages at steps in the pathway are shown in relevant locations. For the temporal timing of the emergence of such domains in eukaryotic evolution, please refer to Figure 1. Domains contributing to post-transcriptional modification, degradation, or amplification of small RNAs are shown to the left of each pathway. For ease in comparison, coloring of RNA and protein domains matches Figure 1. Proteins/domains which participate in RNAi pathways but cannot yet be clearly assigned to any specific pathway are not included. Core domains are labelled in white lettering.