Table 2.

Comparison of clinical data at the baseline and 12-month visit for all 31 subjects included in the post hoc analysis. Data are presented as mean ± standard deviation, median (range), or number (%).

	Baseline (n=31)	12 months (n=31)	P
Biochemical Data
BMI	31 ± 5	32 ± 6	0.16
Serum creatinine, mg/dl	1.7 ± 0.3	1.7 ± 0.4	0.80
eGFR, ml/min/1.73 m2	46 ± 12	47 ± 15	0.95
Serum calcium, mg/dl	9.2 ± 0.3	9.5 ± 0.4	0.70
Serum phosphorus, mg/dl	3.4 ± 0.5	3.2 ± 0.5	0.80
TRP, %	77 ± 10	73 ± 10	0.45
Intact PTH, pg/ml	67 ± 50	71 ± 48	0.52
FGF23, pg/ml*	58 (24, 201)	55 (33, 367)	0.95
Soluble klotho, pg/ml	748 ± 289	536 ± 410	0.03a
FGF23/klotho ratio	0.09 ± 0.07	0.26 ± 0.25	0.01a
Cardiovascular Data †
Systolic BP, mmHg	131 ± 14	130 ± 12	0.69
Diastolic BP, mmHg	77 ± 10	71 ± 8	0.01a
Heart rate, beats per minute	70 ± 10	69 ± 10	0.25
LVM, g	203 ± 79	223 ± 70	0.02a
LVM, g/m2	100 ± 29	106 ± 27	0.03a
LVM, g/m2.7	47 ± 13	53 ± 13	0.006a
LVH, no., %	10 (32%)	15 (48%)	0.33
LVEF, %	62 ± 10	66 ± 9	0.04a
PWV, m/s	10.7 ± 1.8	10.1 ± 2.1	0.08
Diastolic Function †
E velocity (cm/s)	0.57 (0.33, 1.23)	0.58 (0.34, 1.38)	0.74
A velocity (cm/s)	0.71 (0.47, 1.24)	0.69 (0.50, 1.12)	0.25
E/A ratio	0.78 (0.43, 1.50)	0.80 (0.52, 1.75)	0.60
Lateral e’, cm/s	8 (5, 18)	10 (5, 16)	0.10
Lateral E/e′ ratio	6.3 (3.3, 22.8)	6.2 (3.4, 23.6)	0.10
Left atrial volume, ml/m2	51 (21, 128)	53 (26, 118)	0.40
Diastolic dysfunction, no., %	15 (48%)	14 (45%)	1.00

^†Please see the Methods section for normal reference values for the cardiovascular data and diastolic function variables.

^*FGF23 is the only non-normally distributed biochemical variable and is presented as median (range).

^aStatistically significant difference in means between the baseline and 12-month visit using paired t test.