Table 1. Studies on Solid Forms of Btl.
| author(s) | form(s)a | method(s)b | ref |
|---|---|---|---|
| Fischer and Kofler (1932) | I0, III, IV | optical crystallography; HSM, sublimation studies | (4) |
| Lindpaintner (1939) | I0, III, IV, V | HSM, sublimation studies, melt film preparation | (5) |
| Brandstätter (1942) | I0, III, IV | HSM, isomorphism and polymorphism, | (16) |
| Kofler (1947, 1954) | I0, III, IV, V | crystallization (solvents, melt, sublimation), enantiotropic relationship of IV/V in binary system studies | (17) |
| Huang (1951) | I0, III, IV, V | PXRD of impure forms; PXRD of a contact preparation | (6a) |
| Huang (1953) | I0, III, IV, V | identification of solid solutions of aprobarbital (allypropymal) III and Btl-III (“diemal”) | (6b) |
| Cleverley and Williams (1959) | I0, III, Vc | PXRD; IR | (7) |
| Brandstätter-Kuhnert and Aepkers (1962, 1963) | I0, II, III, IV, V, VI | HSM on binary barbiturate systems | (8) |
| Nogami (1969) | I0, III, V | dissolution studies | (12a) |
| Craven et al. (1969, 1971) | I0, III, V | SXRD | (11) |
| Kuhnert-Brandstätter et al. (1971) | I0, III, IV, V | IR | (10) |
| Willis et al. (1972) | III | Raman spectroscopy | (18) |
| Kaliszsan et al. (1975) | I0, III, IVc, Vc | IR; poor quality spectra, interpretation very difficult | (19) |
| Sekiguchi et al. (1975) | I0, III, V | dissolution tests | (12b) |
| Grabowska et al. (1976) | I0, III, IVc, Vc | crystallization studies, thermal analysis, PXRD, interpretation on the basis of the data provided very difficult | (13) |
| McMullan et al. (1978) | III | SXRD from neutron data | (20) |
| Hollenbach et al. (1979–1982) | I0, III | formulation properties (compaction, dissolution etc.) | (12c−12h) |
| Burger and Ramberger (1979) | I0, II, III, IV, V, VI | thermochemical data, thermodynamic relationships between forms | (14) |
| Caillet and Claverie (1980) | I0, III, V | discussion of the structural differences | (21) |
| Craven et al. (1982) | III | charge density study | (22) |
| Chauvet et al. (1986) | I0, III | DTA, TGA | (23) |
| Fournival et al. (1987) | I0, III, V | DTA, TGA | (24) |
a
With reference to the nomenclature system used in this study.
b
Abbreviations: HSM, hot-stage microscopy studies; DTA, differential thermal analysis; TGA, thermogravimetric analysis; PXRD, powder X-ray powder diffraction; IR, infrared spectroscopy.
c
Assignment is doubtful.