Table 2.
[11C]WAY-100635 PET Scan Parameters
| Control Subjects (n = 51) |
Remitters (n = 11) |
Nonremitters (n = 13) |
Remitters Versus Nonremitters p Value |
Control Subjects Versus MDD p Value |
|
|---|---|---|---|---|---|
| Injected Dose (mCi) | 7.99 ± 3.43 | 5.68 ± 1.34 | 5.56 ± 1.62 | .85 | .002 |
| Injected Mass (μg) | 2.98 ± 1.94 | 1.30 ± 1.28 | 1.29 ± .95 | .98 | <.001 |
| Plasma Free Fraction (fP) | 8.09% ± 2.40% | 6.49% ± 1.95% | 6.34% ± 2.05% | .85 | .004 |
| Reference Region Binding | .25 ± .011 | .24 ± .023 | .28 ± .024 | .27 | .60 |
| (volume of distribution, VT(REF), Cerebellar White Matter) |
MDD, major depressive disorder; PET, positron emission tomography.