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Complement activation during cisplatin-induced nephrotoxicity. A: serum complement activity from the mice treated with cisplatin was measured. Values are means ± SE. P < 0.001 vs. 0 time point. B: representative renal tissues stained with anti-C3b/iC3b/C3c antibody. Enhanced staining was observed in the tissues from 24- and 48-h cisplatin-treated mice.
