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. Author manuscript; available in PMC: 2014 Oct 30.
Published in final edited form as: Neuron. 2013 Oct 30;80(3):578–587. doi: 10.1016/j.neuron.2013.10.046

Figure 1.

Figure 1

Different kinds of genetic variation and different approaches to genetic analysis are influenced by human population history. (a) Humans have an eccentric population history, in which small, ancestral populations rapidly expanded into a population of some seven billion individuals. (b) Genetic variants that have arisen recently in human history, including new mutations, are generally ascertained by genome sequencing. (c) Polymorphisms that were already present in the small, ancestral populations can be systematically evaluated for relationship to phenotypes, on thousands of genetic backgrounds, using inexpensive array-based assay platforms.