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. Author manuscript; available in PMC: 2014 Jun 23.
Published in final edited form as: J Med Chem. 2007 Mar 3;50(7):1442–1444. doi: 10.1021/jm061484y

Table 1.

CPE Assay Screening Results.

graphic file with name nihms61998u1.jpg
R Vaccinia EC50(μM) Cowpox EC50(μM) CDVr Cowpox EC50(μM) CC50 (μM)
2 4-nitrophenyl 0.02 0.15 0.10 >86 ± 20
3 4-Me2N-phenyl 2.0 15.5 3.5 >100 ± 0
4 4-aminophenyl 7.7 >20 >50 >92 ± 11
5 2-pyridyl >20 >20 >20 >100 ± 0
6 3-pyridyl 0.74 >20 >5 >100 ± 0
7 4-pyridyl 0.5 17.2 1.8 >100 ± 0
8 2-chlorophenyl 3.0 >20 ND >100 ± 0
9 3-chlorophenyl 0.04 0.6 ND >100 ± 0
10 4-chlorophenyl 0.02 0.77 ND >100 ± 0
11 2-bromophenyl 2.3 >20 4.0 >100 ± 0
12 3-bromophenyl 0.05 0.6 0.03 >100 ± 0
13 4-bromophenyl 0.02 1.6 0.1 >100 ± 0
14 4-CF3phenyl 0.04 0.6 0.07 >100 ± 0
15 sat. 4-CF3phenyl 0.02 0.3 0.02 >100 ± 0
16 4-methoxyphenyl 2.2 >20 3.1 >100 ± 0
17 2-(1-methyl)pyrrolyl 15.8 >20 4.7 >100 ± 0
18 5-(3-methyl)pyrazolyl 7.1 >20 4.6 >100 ± 0