TABLE 1.
Clinical, demographic and neuropathology characteristics by diagnosis category of cases included in the analysis. n/a indicates data not available
| Clinical Diagnosis | ||||
|---|---|---|---|---|
| Aged controls (n=24) |
MCI (n=16) |
AD (n=27) |
||
| Age (years) at death : |
mean ± stdev
(range) |
85.2 ± 6.8 (74-95) |
87.7 ± 4.4 (74-98) |
84.9 ± 6.2 (74-95) |
| Gender distribution: |
females
males |
15 9 |
8 8 |
15 12 |
| MMSE: | mean ± stdev (range) | 29 ± 1.56 (25-30) |
26.5 ± 2.47 (22-30) |
11.9 ± 9.02 (0-27) |
| ApoE4 allele: | number (%) | 2 (8%) | 4 (25%) | 17 (63%) |
| Post-mortem interval (hours): |
mean ± stdev
(range) |
3.8 ± 1.7 (2-6.25) |
5.8 ± 5 (2-14) |
4.4 ± 2.9 (1.5-10) |
| Distribution of Braak scores (n): |
0-II
III-IV V-VI n/a |
15 9 0 0 |
3 11 0 2 |
1 10 15 1 |
| microarrrays used/group (n): | Total | 57 | 44 | 78 |
| microarrays used/region (n): |
EC
HC PCG SFG EC |
9 16 15 17 |
10 8 11 15 |
15 18 24 21 |
|
RNA integrity (RIN)
mean ± stdev: |
EC
HC PCG SFG |
8.67 ± 0.49 8.14 ± 0.75 8.63 ± 0.61 8.66 ± 0.84 |
8.21 ± 0.76 8.94 ± 0.36 8.63 ± 0.84 8.48 ± 0.96 |
8.21 ± 0.77 7.81 ± 0.68 8.44 ± 0.70 8.53 ± 0.76 |