Table 1.

Development of the vanadium-catalyzed C—H fluorination reaction^a

Entry	Catalyst loading	Catalyst	Fluorine source	Yieldb
1	10 mol %	V2O5	A	0%
2	20 mol %	VO(OiPr)3	A	0%
3	20 mol %	VO(OSiPh3)3	A	0%
4	20 mol %	VOF3	A	0%
5	20 mol %	V(O)SO4	A	0%
6	20 mol %	VO2	A	<5%
7	20 mol %	Cp2VCl2	A	<5%
8	20 mol %	VF3	A	<5%
9	20 mol %	VBr3	A	<5%
10	20 mol %	V(acac)3	A	21%
11	10 mol %	V2O3	A	73% (65%)c
12	20 mol %	Cp2V	A	13%
13	10 mol %	V2O3	B	0%
14	10 mol %	V2O3	C	0%
15	10 mol %	V2O3	D	0%
16	10 mol %	–	A	0%

^aConditions: 1 (0.2 mmol), catalyst (0.04 mmol, or 0.02 mmol for V₂O₅ and V₂O₃), Selectfluor (0.3 mmol), CH₃CN (2 mL), 23 °C.

^bBased on crude ¹⁹F NMR spectra using C₆H₅F as the external standard.

^cIsolated yield in parenthesis.