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Climbing up a proteogenomic data ladder. Integrative omics experiments generate tiers of data and knowledge to improve cancer systems biology. Proteogenomic data accumulate at the lower tiers of the data ladder (proteogenomic mapping of linear sequences and protein expression and PTM changes due to genomic alterations), and compress as data analyses become more labor-intensive, complex, and multi-dimensional at the network and pathway level (upper tiers).
