Table 3.
Cases of hypoglycemia from NICTH secreting IGF-2 reported from 2008 till 2012
| Reference | Age/sex | Tumor site | Tumor pathology | Hormone elevated | Management |
|---|---|---|---|---|---|
| [17] |
28, male |
Retroperitoneal pelvic region |
Malignant solitary fibrous tumor |
IGF-2 |
Surgical resection of turmor |
| [18] |
68, male |
Liver |
Solitary fibrous tumor |
Big IGF-2 |
Partial hepatic resection |
| [19] |
59, male |
Lungs and bones |
Meningeal hemangiopericytoma |
IGF-II (elevated IGF-2/IGF-1 levels) |
Interferon alpha |
| [20] |
75, male |
Left pleural cavity |
Pleural solitary fibrous tumor |
Big IGF-2 |
Surgical resection |
| [21] |
65, male |
Retroperitoneal tumor |
Retroperitoneal solitary fibrous tumor |
IGF-2, Big IGF-2 |
Surgical resection |
| [22] |
66, female |
Right inferior thorax |
Solitary fibrous tumor |
IGF-2 |
Surgical resection |
| [23] |
53, male |
Liver |
Metastatic hemangiopericytoma |
Elevated IGF 2/IGF-1 ratio |
Right hepatectomy |
| [24] |
64, female |
Right lower thorax |
Malignant solitary fibrous tumor |
Elevated IGFBP |
Surgical resection, radiation post operatively |
| [25] |
83, male |
Retroperitoneum |
Malignant solitary fibrous tumor |
Big IGF-2 |
Surgical resection |
| [26] |
43, male |
Right posterior cranial fossa, metastatic lesions in bilateral kidney, right iliopsoas muscle, right iliac body, thoracic vertebra 10 body and segment IV of the liver |
Meningeal hemangiopericytoma |
Elevated IGF-2/IGF-1 ratio |
Adriamycin |
| [27] |
59, female |
Right hemithorax |
Solitary fibrous tumor |
Elevated IGF-2/IGF-1 ratio |
Surgical resection |
| [28] |
67, male |
Pelvis |
Solitary fibrous tumor |
Elevated IGF-2/IGF-1 ratio |
Tumor embolization and radiotherapy |
| [29] |
49, female |
Right breast |
Benign Phyllodes tumor |
Big IGF-2 |
Mastectomy |
| [30] |
49, female |
Left breast |
High grade Phyllodes sarcoma |
Big IGF-2 |
Mastectomy |
| [31] |
80, female |
Uterus |
Uterine leiomyoma |
IGF-II, elevated IGF-2/IGF-1 ratio |
Exploratory laparotomy |
| [32] |
69, male |
Spleen, lungs, liver |
Hepatocellular carcinoma |
Elevated IGF-2 mRNA expression |
|
| [33] |
61, male |
Liver |
Poorly differentiated gastric adenocarcinoma |
Big IGF-2, elevated IGF-2/IGF-1 ratio |
Gastrectomy |
| [34] |
27, female |
Lung and liver |
Ovarian germ cell tumor |
Big IGF-2 |
Dexamethasone, recombinant Growth hormone |
| [35] |
53, female |
Right adrenal gland, liver |
|
Elevated IGF-2/IGF-1 ratio |
Phenoxybenzamine |
| [36] |
45, Male |
Pelvis and peritoneum |
Desmoplastic small round cell tumor |
Elvated IGF-2 and IGF-2/IGF-1 ratio |
chemotherapy |
| [37] |
77, male |
Liver and lungs |
Hepatocellular carcinoma |
Big IGF-2 |
chemotherapy |
| [38] | 41, male | Pleura and posterior mediastinum | Solitary fibrous tumor | Big IGF-2 | chemotherapy |