Table 5.
FMRI Activation (%SC and VC) and Laterality Index in the Primary Motor Cortex for Paretic Hand Movements in Individual Patients and for Dominant (R) and Nondominant (L) Hand Tapping in the Healthy Control Group
| Contralateral M1 |
Ipsilateral M1 |
||||||
|---|---|---|---|---|---|---|---|
| Subjects | Task Hand | Time Points | %SC | VC | %SC | VC | LI_M1 |
| Patient 1 | R | Pre | 1.87 | 142 | 0.94 | 144 | −0.01 |
| Post | 1.48 | 318 | 1.65 | 269 | 0.08 | ||
| Patient 2 | R | Pre | 1.33 | 37 | 1.76 | 9 | 0.61 |
| Post | 1.12 | 53 | 0 | 0 | 1 | ||
| Patient 3 | L | Pre | 1.98 | 107 | 1.61 | 394 | −0.57 |
| Post | 1.55 | 242 | 1.79 | 490 | −0.34 | ||
| 6-mo | 1.39 | 180 | 1.41 | 353 | −0.32 | ||
| 12-mo | 1.20 | 421 | 1.38 | 387 | 0.04 | ||
| Patient 4 | R | Pre | 3.01 | 491 | 3.66 | 138 | 0.56 |
| Post | 1.70 | 103 | 1.31 | 25 | 0.61 | ||
| 6-mo | 1.21 | 308 | 0.92 | 22 | 0.87 | ||
| 12-mo | 4.72 | 610 | 4.27 | 264 | 0.40 | ||
| HC (mean ± SE) |
R | Scan 1 | 1.00 (0.11) |
543 (110) |
0.39 (0.16) |
63 (32) |
0.86 (0.06) |
| Scan 2 | 0.95 (0.08) |
548 (88) |
0.60 (0.16) |
39 (17) |
0.90 (0.04) |
||
| L | Scan 1 | 1.64 (0.08) |
536 (65) |
1.27 (0.74) |
114 (47) |
0.73 (0.08) |
|
| Scan 2 | 1.46 (0.14) |
539 (119) |
1.13 (0.28) |
252 (93) |
0.57 (0.13) |
||
fMRI = functional magnetic resonance imaging; %SC =percent signal change; VC = voxel counts; M1 = primary motor cortex; LI_M1= laterality indexof M1 activation from voxel counts; LI_M1 = (contralateral_M1 − ipsilateral_M1)/(contralateral_M1 + ipsilateral_M1); HC = healthy control; Pre = before therapy; Post = immediately after therapy; 6-mo = 6 months after therapy; 12-mo = 12 months after therapy. Data for healthy controls were the average from the 8 subjects who were scanned twice 2 to 3 weeks apart. The ipsilateral M1 activation (%SC and VC) for dominant hands was the average from 3 HC, and that for nondominant hands was the average from 5 HC who showed ipsilateral activation in both fMRI sessions.