Table 1.
Clinical characteristics of study participants at fasting
| Controls | Type 1 diabetes | p | |
|---|---|---|---|
|
Age (yrs) |
38.2 ± 10.3 |
42.5 ± 9.4 |
ns |
|
Sex (M/F) |
18/16 |
16/21 |
ns |
|
Duration of diabetes (yrs) |
- |
26 ± 13 |
- |
|
BMI (kg/m
2
) |
25.2 ± 4.2 |
26.1 ± 3.6 |
ns |
|
Systolic blood pressure (mmHg) |
129 ± 14 |
133 ± 17 |
ns |
|
Diastolic blood pressure (mmHg) |
77 ± 10 |
77 ± 8 |
ns |
|
HbA
1c
(%) (mmol/mol) |
5.3 ± 0.3 (34 ± 3.3) |
8.0 ± 1.3 (64 ± 14.2) |
<0.001 |
|
eGFR (ml/min/1.72 m
2
) |
102 (93–110) |
101 (94–114) |
ns |
|
AER (mg/24 h) |
3.4 (2.4–5.2) |
7.0 (3.8–13.4) |
0.001 |
|
Blood glucose (mmol/l) |
4.9 ± 0.6 |
8.7 ± 3.4 |
<0.001 |
|
Cholesterol (mmol/l) |
4.7 ± 0.7 |
4.6 ± 0.7 |
ns |
|
Triglycerides (mmol/l) |
1.0 ± 0.3 |
0.9 ± 0.5 |
ns |
|
HDL-chol (mmol/l) |
1.3 (1.1–1.7) |
1.6 (1.3–1.8) |
ns |
|
LDL-chol (mmol/l) |
2.8 ± 0.7 |
2.6 ± 0.7 |
ns |
|
ApoB-100 (mg/dL) |
83 (73–93) |
72 (66–87) |
ns |
|
ApoA1 (mg/dL) |
138 (123–158) |
153 (132–162) |
ns |
|
ApoB-48 (mg/dL) |
3.8 (2.7–5.4) |
5.0 (3.7–8.8) |
0.014 |
|
High-sensitive CRP (mg/l) |
1.0 (0.2–2.7) |
1.5 (0.3–5.4) |
ns |
|
Interleukine-6 (pg/ml) |
1.2 (0.8–2.0) |
1.5 (0.5–3.5) |
ns |
| LPS (EU/ml) | 0.82 (0.57–1.43) | 0.90 (0.52–1.24) | ns |
Data at fasting are presented as mean ± SD or median (25th-75th quartile). AER – albumin excretion rate, eGFR – estimated glomerular filtration rate.