Table 3.

Hazard ratio and 95%CI of reinfarction on mortality and subsequent class III–IV heart failure (HF) using Cox proportional hazard model. Reinfarction was fit as a time-dependent variable.

Sub-group and Comparison		Unadjusted			Adjusted*
		Hazard Ratio	95% CI	p-value	Hazard Ratio	95% CI	p-value
Reinfarction by Universal Definition
Reinfarction on Death
Overall	ReMI vs. noReMI**	4.80	3.52–6.53	<0.001	4.15	3.03–5.69	<0.001
PCI	ReMI vs. noReMI	4.26	2.79–6.52	<0.001	3.64	2.35–5.64	<0.001
MED	ReMI vs. noReMI	5.80	3.69–9.10	<0.001	4.90	3.09–7.75	<0.001
Early and Late Reinfarction on Death
Cutoff=6 months	Early ReMI vs. noReMI	3.21	2.04–5.07	<0.001	2.55	1.60–4.05	<0.001
Cutoff=30 days	Late ReMI vs. noReMI	6.23	4.49–9.79	<0.001	6.22	4.18–9.27	<0.001
	Early ReMI vs. noReMI	3.09	1.69–5.65	<0.001	2.25	1.21–4.16	0.010
	Late ReMI vs. noReMI	5.56	3.93–7.87	<0.001	5.08	3.56–7.25	<0.001
Reinfarction on Class III–IV HF
Overall	ReMI vs. noReMI	3.08	1.61–5.91	<0.001	2.66	1.37–5.17	0.004
Reinfarction by OAT Definition
Reinfarction on Death
Overall	ReMI vs. noReMI	3.43	2.39–4.92	<0.001	3.22	2.24–4.65	<0.001
PCI	ReMI vs. noReMI	2.43	1.42–4.17	0.001	2.27	1.31–3.92	0.003
MED	ReMI vs. noReMI	5.10	3.13–8.30	<0.001	4.35	2.65–7.15	<0.001
Early and Late Reinfarction on Death
Cutoff=6 months	Early ReMI vs. noReMI	2.48	1.45–4.25	0.001	2.08	1.21–3.58	0.008
Cutoff=30 days	Late ReMI vs. noReMI	4.47	2.81–7.10	<0.001	4.84	3.02–7.76	<0.001
	Early ReMI vs. noReMI	2.72	1.35–5.50	0.005	2.39	1.17–4.88	0.016
	Late ReMI vs. noReMI	3.69	2.45–5.56	<0.001	3.57	2.35–5.41	<0.001
Reinfarction on Class III–IV HF
Overall	ReMI vs. noReMI	2.81	1.37–5.78	0.005	2.78	1.34–5.76	0.006

^*Adjusted for baseline factors that included heart failure at baseline, history of cerebrovascular disease, diabetes history, PCI history, age (10-years interval), ejection fraction (10% interval). For all the overall models, treatment group (PCI vs. MED) was included in the controlled factors.

^**ReMI: Reinfarction; noReMI: Without reinfarction.