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. Author manuscript; available in PMC: 2014 Jun 23.
Published in final edited form as: Front Biol (Beijing). 2013 Apr 1;8(2):228–233. doi: 10.1007/s11515-012-1211-5

Figure 1.

Figure 1

A model of transcription regulation using “histone mimicry”. A) Transcription factor(s) interacts with a specific histone-modifying enzyme using its histone-mimicking motif. B) The transcription factor binds its target gene using the DNA-binding domain, thus recruiting the enzyme to the chromatin region. C) The overabundant amount of histone proteins at the chromatin region outcompetes the histone-mimicking motif for enzyme-binding, allowing the enzyme to modify histone and regulate target gene transcription.